Our laboratory has published extensively in high-impact journals, advancing the understanding of brain tumor immunology and developing novel therapeutic approaches. Below are selected publications grouped by principal investigator.
Selected Key Publications
CAR-T Cell Therapy & Immunotherapy
CXCR1- or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
Nature Communications 10 (1), 4016
CD70, a novel target of CAR T-cell therapy for gliomas
Neuro-Oncology 20 (1), 55-65
Blocking immune checkpoint LAIR1 with antibody blockade or 3-in-1 CAR T cells enhances antitumor response
The Journal of Clinical Investigation
Glioblastoma Biology & Resistance Mechanisms
Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Pharmacological Research 171, 105780
Dysregulation of glutamate transport enhances Treg function that promotes VEGF blockade resistance in glioblastoma
Cancer Research 80 (3), 499-509
Tumor Microenvironment & Immunosuppression
Tumor associated CD70 expression is involved in promoting tumor migration and macrophage infiltration in GBM
International Journal of Cancer 141 (7), 1434-1444
The IDH1 mutation-induced oncometabolite, 2-hydroxyglutarate, may affect DNA methylation and expression of PD-L1 in gliomas
Frontiers in Molecular Neuroscience 11, 82
Translational & Clinical Studies
Multimodal in vivo tracking of chimeric antigen receptor T cells in preclinical glioblastoma models
Investigative Radiology 58 (6), 388-395
CAR T cell locomotion in solid tumor microenvironment
Cells 11 (12), 1974
Publications by Year
Professor Zhan Renya
For a complete list of Professor Zhan’s publications (111 papers), please see our data files. Selected recent publications include:
2025
Primary cerebellar angiosarcoma: a rare case report and literature review
BMC Surgery
In Situ Ferroptosis with Global Dynamics Visualization for Glioblastoma Theranostics
Journal of Medicinal Chemistry
Tumor Marker Test in Cerebrospinal Fluid for Leptomeningeal Metastasis Diagnosis and Response Assessment in Non-Small-Cell Lung Cancer
European Journal of Neurology
Septicemia following sudden pituitary apoplexy after bladder tumor surgery: a case report
BMC Neurology
2024
Predicting Prognosis and Immunotherapy Response in Glioblastoma (GBM) With a 5-Gene CAF-Risk Signature
Cancer Reports
Multipoint Aspiration Technique Improves Hematoma Evacuation Efficiency and Functional Outcomes in Stereotactic Catheter Aspiration for Spontaneous Intracerebral Hemorrhage
World Neurosurgery
2023
Iron enhances reactive oxygen species generation and initiates neutrophil extracellular traps formation on the endothelium to exacerbate stroke
Journal of Cell Communication and Signaling
2022
Anoctamin-1 is a core component of a mechanosensory anion channel complex in C. elegans
Nature Communications
Dr. Jin Linchun
For a complete list of Dr. Jin’s publications (152 entries), please see ResearchGate and Google Scholar. Selected recent publications include:
2025
Blocking immune checkpoint LAIR1 with antibody blockade or 3-in-1 CAR T cells enhances antitumor response
The Journal of Clinical Investigation
In Situ Ferroptosis with Global Dynamics Visualization for Glioblastoma Theranostics
Journal of Medicinal Chemistry
Chimeric lactate receptor engineered t cells
US Patent App. 18/842,078
2024
CD70 CXCR2-Modified CAR T-Cells Against Acute Myeloid Leukemia
Transplantation and Cellular Therapy 30 (2), S178-S179
IMMU-21. OVEREXPRESSING CAR T-CELL GLUCOSE TRANSPORTER TO ENHANCE ANTI-TUMOR ACTIVITY IN GLIOBLASTOMA
Neuro-Oncology 26 (Suppl 8), viii156
2023
Multimodal in vivo tracking of chimeric antigen receptor T cells in preclinical glioblastoma models
Investigative Radiology 58 (6), 388-395
Chimeric antigen receptor t-cells expressing interleukin-8 receptor
US Patent 11,788,093
Bioconjugated liquid-like solid enhances characterization of solid tumor-chimeric antigen receptor T cell interactions
Acta Biomaterialia 172, 466-479
2022
CAR T cell locomotion in solid tumor microenvironment
Cells 11 (12), 1974
2021
Glioblastoma multiforme (GBM): An overview of current therapies and mechanisms of resistance
Pharmacological Research 171, 105780
Optimizing T cell-based therapy for glioblastoma
Frontiers in Immunology 12, 705580
2020
Dysregulation of glutamate transport enhances treg function that promotes VEGF blockade resistance in glioblastoma
Cancer Research 80 (3), 499-509
2019
CXCR1-or CXCR2-modified CAR T cells co-opt IL-8 for maximal antitumor efficacy in solid tumors
Nature Communications 10 (1), 4016
2018
CD70, a novel target of CAR T-cell therapy for gliomas
Neuro-Oncology 20 (1), 55-65
The IDH1 mutation-induced oncometabolite, 2-hydroxyglutarate, may affect DNA methylation and expression of PD-L1 in gliomas
Frontiers in Molecular Neuroscience 11, 82
CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma
Oral Oncology 78, 145-150
2017
Tumor associated CD70 expression is involved in promoting tumor migration and macrophage infiltration in GBM
International Journal of Cancer 141 (7), 1434-1444
CD4+ and perivascular Foxp3+ T cells in glioma correlate with angiogenesis and tumor progression
Frontiers in Immunology 8, 1451
Patents
-
Chimeric antigen receptor T-cells expressing interleukin-8 receptor
J Huang, L Jin
US Patent 11,788,093 (2023) -
Chimeric lactate receptor engineered T cells
L Deleyrolle, D Mitchell, J Huang, L Jin
US Patent App. 18/842,078 (2025)
Note: This page shows selected publications. Complete publication data will be populated from YAML data files. Citations counts are approximate and may not reflect the most current numbers.