People

Professor Zhan Renya, M.D., Ph.D.

Professor | Doctoral Supervisor | Department Chief

Department of Neurosurgery, First Affiliated Hospital, Zhejiang University School of Medicine

Contact: 1196057@zju.edu.cn

Biography

Professor Zhan graduated from Zhejiang Medical University with a BA degree in medicine in 1983. He received his master's degree in neurosurgery from Zhejiang Medical University in 1991, and studied at the University of Kiel in Germany from 1998 to 2002, receiving his Ph.D. in neurosurgery in 2002.

He is a well-known expert in neurosurgery and serves as Director of the Department of Neurosurgery at the First Affiliated Hospital, School of Medicine, Zhejiang University. He is also the director-designate of Zhejiang Neurosurgery Medicine Association, the Zhejiang Neuro-oncology Anti-Cancer Association, and serves on multiple committees including the Chinese Congress of Neurological Surgeons and the Expert Committee of Cerebral Vascular Disease.

Clinical & Research Expertise

Professor Zhan has been engaged in clinical neurosurgery for over 30 years, specializing in:

• Traumatic brain injuries
• Brain tumors and neuro-oncology
• Cerebrovascular diseases
• Spinal cord tumors
• Functional neurosurgery

Recognition & Awards

• 2014 Wang Zhongcheng Academic Achievement Prize
• 2009 Second Prize, Zhejiang Medicine Health Innovation
• 2009 Third Prize, Zhejiang Science and Technology Progress
• 2007 Second Prize, Zhejiang Scientific and Technological Universities Innovation

Research Contributions

Professor Zhan has published over 110 academic papers in prestigious journals including Nature Communications, Journal of Neurosurgery, Medicine, Critical Care, World Neurosurgery, and Acta Neurochirurgica. He has led numerous research projects funded by the National Natural Science Foundation of China and Zhejiang Natural Science Foundation, focusing on cerebrovascular disease, glioma metabolism, neural stem cells, and traumatic brain injury.

Dr. Jin Linchun (Lunchun Jin)

Head of Laboratory | Principal Investigator

Verified affiliation: University of Florida, Department of Neurosurgery

Contact: linchun.jin@zju.edu.cn

Research Interests

Dr. Jin's research focuses on brain tumor immunotherapy, with particular expertise in:

• CAR-T cell therapy for glioblastoma and solid tumors
• Novel target antigen discovery (CD70, CXCR1/2, LAIR1)
• Tumor microenvironment and immunosuppression
• Metabolic engineering of T cells for enhanced anti-tumor activity
• Combination immunotherapy strategies

Key Contributions

Dr. Jin has made pioneering contributions to CAR-T cell therapy for glioblastoma, including:

• Development of CD70-targeted CAR-T cells for gliomas
• Engineering CXCR1/2-modified CAR-T cells that co-opt IL-8 for enhanced tumor trafficking
• Discovery of LAIR1 as a novel immune checkpoint in glioblastoma
• Multiple patent applications including chimeric antigen receptor T-cells expressing IL-8 receptor (US Patent 11,788,093)

Selected Publications

Dr. Jin has authored over 150 publications with more than 600 citations for lead articles. Notable works include:

• Nature Communications (2019): CXCR1/2-modified CAR T cells co-opt IL-8 - 320+ citations
• Neuro-Oncology (2018): CD70 as a novel CAR-T target - 209 citations
• Pharmacological Research (2021): GBM therapies and resistance mechanisms - 604 citations
• Cancer Research (2020): Glutamate dysregulation and VEGF resistance - 106 citations

For a complete publication list, please see ResearchGate and Google Scholar.

He Haifeng

Ph.D. Candidate, Zhejiang University School of Medicine

MUNGUR Rajneesh

Ph.D. Candidate, Zhejiang University School of Medicine

Research focus: Ferroptosis and glioblastoma theranostics

Shi Rui

Master of Medicine, Zhejiang University School of Medicine (Graduated)